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HGF and MET are expressed by stromal and malignant cells, respectively

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Keywords Liver disease, Gutliver axis, Gut microbial dysbiosis, Microbial metabolites, Gut barrier, Ecological niche remodeling, Therapeutics, Multi-omics Introduction Liver diseases are one of the leading causes of death and disability worldwide, with a broad spectrum ranging from metabolic dysfunctionassociated steatotic liver disease (MASLD)/nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and viral hepatitis to cirrhosis and hepatocellular carcinoma (HCC)

P73 in the Hippo pathway can play an antitumor role, and P53 mediates the transcriptional repression of SLC7A11 to promote the ferroptosis of cancer cells (Vogel et al., 2014)