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Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages

Levels of active G6PD are regulated at both the transcriptional level via various canonical signaling pathways (e.g., JAK-STAT, Wnt, mTOR), and at the post-translational level (e.g., via phosphorylation, de-acetylation), allowing tight coordination of G6PD activity to meet acute cellular demand in response to oxidative stress, metabolic demand, or systemic inflammation ( Figure 1A-1 )