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The pentose phosphate pathway is divided into an irreversible redox stage, which yields both NADPH and pentose phosphates, and a reversible interconversion stage, in which excess pentose phosphates are converted into glycolytic intermediates

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HIF-1 in renal cell carcinoma inhibits the activity of CPT1 on the outer mitochondrial membrane and prevents the -oxidation of fatty acids (398), which is important for the differentiation of Treg cells, and its blockade could prevent the accumulation of this immunosuppressive population (199)