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117 Furthermore, among coronary artery disease patients, those with concurrent type 2 diabetes mellitus demonstrate even higher levels of serum GST activity, pointing towards marked oxidative stress within this subgroup
3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimers disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular -amyloid (A) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability (Hooper et al., 2025)
doi: 10.1016/j.ejphar.2013.05.048