As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
Sources & References 1RPEP-13892Vasireddi, Nikhil et al
Skin Radiance Glutathione speeds up cell renewal in both young and old people
Repeated treatments sustained hypoxia alleviation without resistance, highlighting a translatable strategy for CRC (139)
The supplement aids in detoxification and improves energy levels