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However, nicotine is a well-known irritant of the pharynx 17 , and increasing nicotine levels in the inhaled aerosol can lead to acceptability issues such as harshness, irritancy, and coughing

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Individuals who smoke tend to limit their social, career and travel opportunities, as engaging in many of these areas while smoking can be extremely difficult

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De Mornay is also known for her roles in The Slugger's Wife (1985), Runaway Train (1985), The Trip to Bountiful (1985), Backdraft (1991), and The Hand That Rocks the Cradle (1992)