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The ER-resident GPx7 or GPx8 isoforms protect -cells of insulin-secreting INS against lipotoxicity by enhancing the antioxidant capacity of ER without compromising insulin production and oxidative protein folding mechanisms [19, 59]

doi: 10.1073/pnas.1808576115

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Bilayer and Janus-type scaffold configurations have also demonstrated spatially organized control of moisture balance, antioxidant release, and cellular migration highlighting the role of architectural hierarchy in directing healing outcomes