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20% of NB patients and drives half of the aggressive forms of the disease with poor outcomes ( MYCN transcriptional machinery, synthetic lethality, and destabilization of the MYCN protein ( NB, like other malignancies, is associated with modifications in cellular metabolism that may contribute to oncogenesis

Research should employ quantitative methods to assess these questions including stability assays, pharmacokinetic studies, and comparative efficacy assessments

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The rationale for combining them, as explored in published research, is potential additive or synergistic engagement of these separate receptor systems