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Those with active malignancy, certain pituitary issues, or poorly controlled diabetes may not be appropriate and require careful medical evaluation first

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95 Furthermore, other literature suggests that JS-K inhibits angiogenesis, 96 induces cell apoptosis (a process related to PARP, caspase 8 and 9 cleavage, and cell differentiation), 95,97 destroys double-stranded DNA, 95,9799 and is also able to interfere with the cell cycle and its respective signaling pathways

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