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Downstream target proteins of the pathway include heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, glutathione peroxidase 1, glutathione S-transferase (GST), glutathione reductase (GR), and superoxide dismutase (SOD) [37,38]

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Glutathione - Synthesis SFRBM Education Program Dickinson et al.8 de novo synthesis - 2 The first enzyme of the two enzymes, according to IUBMB nomenclature, is properly called glutamate-cysteine ligase (GCL, E.C