Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms
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Tan H, Zhou H, Guo T, Zhou Y, Zhang Q, Zhang Y, Ma L (2023) Recent advances on formation, transformation, occurrence, and analytical strategy of modified mycotoxins in cereals and their products
When applied to skin, it's converted through a two-step enzymatic process - first to retinaldehyde, then to retinoic acid - before it becomes biologically active
Studies of another thiol-containing antioxidant N -acetylcysteine (NAC), at its intrinsic pH, showed that it destabilizes the biofilm matrix by chelating divalent cations (e.g., Ca 2+ and Mg 2+ ), inhibition of bacterial extracellular polysaccharide production, modulation of bacterial cell physiology and the impact on its metabolism ( Our investigation of H 2 O 2 production by GSH during disruption and killing of MRAB biofilms produced interesting results (Figures 5CE)
