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If PAD patients don't seek treatment or follow the doctor's advice, their disease has a higher chance of becoming chronic limb-threatening ischemia, which means that the blood flow to the limb usually a foot and/or leg is so poor that the survival of the limb is in jeopardy

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Anticardiolipin antibody (ACA) is an autoantibody that uses negatively charged cardiolipin on the platelet and endothelial cell membrane as the target antigen and is commonly detected in patients with systemic lupus erythematosus and other autoimmune diseases (157)