glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells Glutathione depletion and dual-model oxygen

G alpha(i/o)-coupled receptor signaling restricts pancreatic beta-cell expansion

These findings were further corroborated by Western blot analysis, in which we observed increased -H2AX expression, decreased pNPM1 (T199) protein levels and increased expression of autophagosome LC3A/B proteins (Fig

Lancet 406 , 135148 (2025)

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That changed with two landmark trials