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found that induction of haem oxygenase-1 through activation of the Nrf2-ARE pathway protected melanocytes from H 2 O-induced toxicity and that upregulation of Nrf2 expression reduced H 2 O 2 -induced apoptosis of human melanocytes [27]

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Furthermore, glutamine-derived fumarate, malate, and citrate are significantly increased when glucose is deprived, demonstrating that glutamine drives the glucose-independent TCA cycle in a nutrient-poor tumor microenvironment (Le et al., 2012)

Funding This study was supported by the Beijing Natural Science Foundation (No

Therefore, in this review, we discuss the fundamental mechanisms of ferroptosis and its relationship with the pathophysiology of various kidney diseases, and we describe potential therapeutic approaches targeting ferroptosis