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Moreover, it has been found that TQ can directly modulate the activation of several signal transduction pathways including PI3K-Akt-mTOR that are frequently upregulated in various cancers and confer resistance to radiotherapy (Baskar et al., 2014

A double-blind placebo-controlled phase I trial (123) demonstrated that berberine reduced colonic tissue inflammation (Geboes score) (224) in mesalamine-treated UC patients

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