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Studies were deemed high quality on MMAT, CONSIDER, or MORI if they met 50% of the relevant criteria, consistent with previous reviews recently undertaken [17, 20]

Factors that influence how quickly addiction develops include: Frequency of nicotine use Nicotine concentration and delivery method Age of first exposure Genetic vulnerability Mental health and stress levels How Nicotine Affects the Brain Nicotine stimulates the release of dopamine in the brains reward system

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Studies show that light, passive smokers typically have cotinine levels below 5 ng/ml, whereas heavy, passive smokers may reach 10 ng/ml or slightly higher

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