The loss of Glutathione, a vital antioxidant, leads to increased oxidative stress and skin damage
Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits -glutamylcysteine synthetas (-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc system) [126, 127]
When NRF2 is hyperactive, it drives the expression of metallothioneins, small cysteine-rich proteins that avidly bind zinc, copper, and cadmium, effectively acting as a metal buffer that soaks up drugs like cisplatin which form platinum-DNA adducts, sequestering them before they can do harm
Therapeutic Potential These mechanisms make Pal-GHK a useful peptide for wound healing and cosmetic applications
Thiamine is found in most B Complex supplements