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IGF Signaling Pathways IGF binding protein-3 (IGFBP-3) is the major carrier of IGF-1 in serum
Two key enzymes, ADH (alcohol dehydrogenase) and ALDH (aldehyde dehydrogenase), are responsible for metabolizing alcohol, by helping to break down alcohol molecules into smaller parts that can then be eliminated
These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [16,17,18,19,20,21,22,23]
10.1080/13547500400024768 Biomarkers
The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks
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