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Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans

As research has progressed, it has become clear that a relatively small set of clock genes generates highly precise timing signals that cascade to influence a broad array of cellular functions ( The circadian regulation of gene expression plays a fundamental role in maintaining physiology

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Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, et al

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