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Werner, R., Armstrong, T

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Additionally, continued exposure of T cells at sites of inflammation elicits high levels of reactive oxygen species (ROS), which results decreased intracellular levels of GSH, dysregulation of redox balance, impaired signal transduction of the TCR/CD3 complex, and ultimately to synovial T cell hyporesponsiveness during RA [137]

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A decrease in 8-isoprostane, a marker of oxidative stress in lipids, was observed in two studies (6, 23)

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