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For instance, it was reported that 25 mM lanosterol failed to reverse opacification of human senile cataract nuclei (161) and had little effect on the nuclear cataracts of cynomolgus monkeys (150)

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In intervertebral disc degeneration, activation of Nrf2 through the p62Keap1 loop enhances autophagy and reduces oxidative damage in nucleus pulposus cells

Issa G, Bidikin A, Venugopal S, Konopleva M, DiNardo C, Kadia T, Borthakur G , Jabbour E, Pemmaraju N, Yilmaz M, Short N, Maiti A, Sasaki K, Masarova L, Pierce S, Takashi K, Tang G, Loghavi S, Patel K, Andreeff M, Bhalla K, Garcia-Manero G, Ravandi F, Kantarjian H, Daver N