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The jump from 4 mg to 8 mg retatrutide is the biggest escalation step and commonly produces the most significant GI effects

Local injection site reactions were uncommon in the Phase 2 trial, occurring at a lower frequency than systemic gastrointestinal events

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Histological examination of burned skin sections with hematoxylin-eosin and Masson staining showed better granulation tissue formation, re-epithelialization, dermal remodeling, and a higher extent of collagen deposition than the untreated rats (control group)