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Furthermore, 7nAChRs are involved in neurotransmitter release regulation, intracellular signaling, and neuroprotective transcriptome profiles, implicating their role in learning, memory, and anti-inflammatory responses relevant to ASD [46]

FIGURE 4 3.1 Modulation of inflammatory signaling pathways 3.1.1 Inhibition of nuclear Factor- B (NF- B) pathway Glycyrrhizin exerts anti-inflammatory effects and directly protects hepatocytes by regulating genes such as interleukin-4 (IL-4), fibroblast growth factor 10 (FGF10), inhibiting Inhibitor of kappa B (I B) phosphorylation and p65 nuclear translocation to suppress NF- B activation in hepatocytes, thereby reducing the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) (Figure 4)

Melanin-rich skin often responds to everyday triggers with more visible post-inflammatory hyperpigmentation, so avoiding repeated flare ups is as important as fading existing spots

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