Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice
In vitro and in vivo activity of lucitanib in FGFR1/2 amplified or mutated cancer models
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Esmeralda, The Orchid Society of Eastern Himalaya & The Directorate of Cinchona & Other Medicinal Plants 1, 7280 (2015)
These observations highlight its potential to support cellular homeostasis and investigate mechanisms of aging in experimental systems