The literature describes a molecule that signals cellular processes operating on timescales of weeks to months
Combined with our other results, this suggests that the chemotherapeutic action of PAT is more likely to occur through inhibition of parasite TGR and than of PFK, or that inhibition of both enzymes provides a synergistic antiparasitic affect
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The steady state A * of A, written in terms of the steady states of E, H and C is given by the positive root of the quadratic equation Where The steady state G * , Z * , C * of G, Z and C are given in terms of the steady states H *, N * of H and N respectively are E * the steady state of E is given by the positive root of the quadratic equation The steady state H * of H in terms of the steady state N * of N are H * = 0 and The case when H * = 0, the steady states of A, E and C are given by Hence the steady state of N corresponding to H * = 0 is the positive root of the quadratic equation where where Equilibrium points corresponding to H * = 0 and H * = H max are given in Table 3
10.1016/S0140-6736(05)66456-2