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The diagnosis is based on the finding of cysteinylglycinuria and decreased activity of dipeptidase, and is established by: Increased urinary excretion of cysteinyl glycine Normal concentration of cysteinyl glycine in plasma Low activity of dipeptidase in cultured skin fibroblasts and/or red blood cells

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However, the cartilage tissue generated from FOXO4-DRI pretreated PDL9 cells displayed lower expression of senescence-relevant secretory factors than that from the untreated control group

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