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The body composition shift that tesamorelin produces is therefore a two-sided change: visceral fat goes down, lean mass is maintained or improved, and the ratio between fat and muscle in the abdominal region moves in a favorable direction even when total body weight changes only modestly

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Related studies have demonstrated that PGC-1 exerts a dual regulatory effect on mitochondrial dynamics

Curcumin attenuates ferroptosis-induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway