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Signal Amplification: Activated receptors trigger G-protein coupling, adenylyl cyclase activation, and dramatic increases in intracellular cAMP (often 10-100 fold elevation)

Cell 171 , 64254 e12 (2017)

doi:10.5301/ijao.5000024

These findings imply a significant positive effect with age and accelerate inflammation: following the step of initial dysbiosis and inflammation cascade, the altered GM and persistence of inflammation may act synergistically, prolonging the proinflammatory status