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This feed-forward mechanism is particularly damaging for dopaminergic neurons as their already high metabolic burden makes them unable to withstand this additional loss of GSH, resulting in apoptosis (Leathem et al., 2022)

The reversal of NET function results in efflux of cytoplasmic norepinephrine, normally contained in the , readily releasable pool 12) into the synaptic cleft, independent of calcium influx and the normal process of vesicular release (Raiteri and Levi, 1986

10.1007/s00299-005-0928-x 138 SatohK.KondohH.De LeonT

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