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Additionally, In the limited head-to-head trials available, ALC demonstrated comparable effectiveness to commonly used antidepressants, especially, Selective Serotonin Reuptake Inhibitor (SSRI), Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), Tetracyclic Antidepressant (TeCA), Noradrenergic and Specific Serotonergic Antidepressant (NaSSA), Atypical Antipsychotics like Amisulpride used at low doses for antidepressant effects in this meta-analysis

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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs