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doi: 10.1016/j.ygeno.2021.01.022 70 ShuK.LiuX

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In RA model, some natural medicines (such as resveratrol, baicalin and -mangiferin) antagonize the transcriptional activity of NF-B by up-regulating the expression of SIRT1, thereby inhibiting the expression of a variety of inflammatory cytokines (such as TNF, IL-6 and IL-1), and inhibiting the proliferation, invasion and migration of FLSs, which has a positive effect on RA

By neutralizing reactive oxygen species, it prevents the breakdown of collagen and elastin