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Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

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The market for these drugs, growing at a 2.81% CAGR from 20202033, was $14.09 billion in 2024, projected to reach $14.48 billion in 2025 and $18.08 billion by 2033 (C)