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HCV Treatment Outcomes Among Persons with Alcohol Use Most of the studies that have addressed whether alcohol use impacts treatment outcomes were performed in the pre-DAA treatment era and results from these studies were mixed.[9,60,61] In the DAA treatment era, a large observational study out of the Veterans Affairs (VA) healthcare system evaluated the impact of alcohol use on HCV DAA-based treatment outcomes.[62] Of the 15,151 persons who initiated DAA therapy and had a documented AUDIT-C score, 68.5% were categorized as abstinent, 22.6% as low-level drinking, and 8.9% as unhealthy drinking

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