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32 Even oral intake of high doses of glutathione does not lead to high enough serum levels to be of therapeutic value

The main practical disadvantages are: poor absorption in standard capsule form, the need for consistent daily use over 8-12+ weeks before visible results, relatively higher cost for well-absorbed formats, mild and uncommon side effects like digestive discomfort or headache in some users, and the risk of unrealistic expectations from aggressive marketing claims

PMID: 4 HowKYSongKPChanKG

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The difficulty is the same as with transporters in the BBB