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2.2.3 Thermal stress of myocytes treated with astaxanthin AX at a concentration of 12 mg/mL was diluted with a complete cell culture medium to prepare working solutions with concentrations of 0 M, 2 M, 5 M, 10 M, and 20 M

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For instance, upregulating GPX4 in ferroptosis-sensitive chondrocytes, restoring antioxidant defenses in inflammatory synovial macrophages, or rebalancing iron export in subchondral osteoblasts may prevent tissue-specific degeneration