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BMAA may be implicated in the high incidence of ALS in Guam, where these bacteria are commonly found in the seeds of the Cycas circinalis plant (Banack 2010)
Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin-dependent diabetes
To improve the stability of CPPs, replacement of L-amino acids with D-variants or unnatural amino acids and PEGylation can be considered (Wang et al., 2022)
(II) Increased temperatures can lead to localized overheating, causing cellular necrosis and disrupting tight junction protein structures, so enhancing the permeability of the BBB and ultimately resulting in neurological damage and dysfunction
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