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Early animal studies produced compelling results

Further studies have revealed two compensatory downstream molecular pathways within the Hippo pathway: the Yes-associated protein (YAP) - S-phase kinase-associated protein 2 (SKP2) pathway and the WW domain-containing transcription regulator 1 (TAZ) - ERM protein 1 (EMP1) - NADPH oxidase 4 (NOX4) pathway

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