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Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

Redness, itching, or mild irritation at the application site can occur, particularly during initial use or with higher concentrations

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The CAS registry number for AOD9604 is 221231-10-3

One proposed mechanism is that low B12 may influence adipogenic gene expression through hypomethylation [27], though further mechanistic studies are needed to confirm this pathway