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This is in line with the view of the SIS (Swedish Institute for Standards): 'The maximum total nicotine allowed per consumable shall be 20mg

Update: interim guidance for health care providers evaluating and caring for patients with suspected e-cigarette, or vaping, product use associated lung injuryUnited States, October 2019

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Continuous ingestion and inhalation of tobacco-derived toxins perturb this finely tuned ecosystem, leading to widespread alterations in microbial composition, metabolite profiles, and mucosal barrier integrity