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Delayed treatment may fail to mitigate the oxidative cascade, while early intervention could interfere with beneficial immune responses that rely on ROS for pathogen clearance (Forman and Zhang, 2021)

The overall mortality rate is low (2%-3%), although it is higher among elderly or debilitated patients (10%-20%) and patients with fulminant colitis or toxic megacolon (30%-80%)

crucial cofactors for countless enzymatic reactions essential for skin repair, regeneration, and potent antioxidant defense

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Excessive ROS levels can induce transcription factors like nuclear factor-kappa B (NF-kB), which is accountable for regulating cell growth and oncogenesis [37, 39]