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In rodent models, BPC-157 has been shown to upregulate endothelial nitric oxide synthase (eNOS) and modulate NO production in a context-dependent manner

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For example, peptide YY and glucagon-like peptide-1 (GLP-1) are released in response to food intake and influence appetite and glucose metabolism, with receptors in the brain that affect satiety and cognitive function [43]

This distinction is important and helps explain why the relationship between folate and cancer is more complex than simple claims of benefit or harm