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For adults, the usual dose is 1000 mcg (1 mg) per shot

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Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

Reduction in median DTN times between the first (45 min) and second (39 min) period were significant (p = 0.003, with an increase on the third period (42 min)