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Unrestricted searches at the UniProtKB/Swiss-Prot databases were carried out using the Expasy ScanProsite tool and the Protein BLAST Basic Local Alignment Search Tool ( The list of results was manually curated for amino acids at positions 3-4 and 6 seen in the heat maps and sequence logos of previously identified mimotopes and stimulatory peptides ( Supplementary Figure S1A , Supplementary Table S1 )

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