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Conversely, sleep deprivation skews immune balance, reducing the number and function of natural killer cells (De Lorenzo et al., 2015), impairing T-cell responsiveness (Tune et al., 2021), and elevating circulating proinflammatory cytokines, thus mimicking an inflammaging-like profile even in younger individuals (Garbarino et al., 2021)

Understanding the representative gut microbiota dysbiosis in metformin-treated type 2 diabetes patients using genome-scale metabolic modeling

Some people feel improvement in fatigue sooner, but blood markers and neurologic symptoms may take longer to assess

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