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Its 2022 disclosure by Coskun and colleagues (Cell Metabolism) marked a deliberate extension of the dual-incretin agonist concept pioneered by tirzepatide, adding glucagon receptor engagement to the pharmacological palette

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Similarly, HCT116 cells treated with the pan-Raf kinase inhibitor AZ628 (~100-fold higher than the IC 50 ) also yielded a small percentage of DTPs, amounting to ~0.70% of the starting population ( Figures 1B, D, E )