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There are practical reasons too: B can be unstable if mixed with certain other vitamins in solution, and dosing schedules for B deficiency (pernicious anemia, for instance) may differ

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More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)